Heavy-metal-based nano-objects have been recently shown to act as radiosensitizers. One possible underlying mechanism causing this effect is the amplification of reactive oxygen species (ROS) production upon irradiation. This reaction could be utilized to improve radiotherapy by repolarizing M2 anti-inflammatory macrophages, which typically constitute the majority of the tumor-associated macrophage population, to the M1 pro-inflammatory phenotype that induces anti-cancer responses, as ROS upregulation has been associated with M1 polarization.

Aim: To explore (1) the experiences of pharmaceutical technical assistants (PTAs) and pharmacists regarding the implementation of PTAs in ward-based pharmaceutical care, and (2) interprofessional perspectives of PTAs, pharmacists, and nurses to identify opportunities for improved collaboration and work processes.

Interferon-gamma release assays (IGRAs) have largely replaced the tuberculin skin test (TST) for diagnosing TB infection (TBI) in low-TB-burden countries, except in young children. This review assesses the diagnostic accuracy of IGRAs in children under 5 years old, using TST as a reference, for detecting TBI.

International migration is often driven by the desire to improve one’s well-being. For many, moving abroad represents a pathway to better economic opportunities, social conditions, or personal safety. Yet, not all individuals who aspire to migrate are able to do so. Involuntary immobility—a condition in which people wish to migrate but are constrained by external barriers such as legal restrictions, financial limitations, or lack of resources—may pose a significant challenge to subjective well-being.

High-throughput techniques for biological and (bio)medical sciences often result in read counts used in downstream analysis. Nowadays, complex experimental designs in combination with these high-throughput methods are regularly applied and lead to correlated count-data measured from matched samples or taken from the same subject under multiple treatment conditions. Additionally, as is common with biological data, the variance is often larger than the mean, leading to over dispersed count data.

The cerebellum, long recognized for its role in motor functions, has become increasingly acknowledged for its involvement in a broader spectrum of cognitive functions. Given the cerebellum’s strong neuronal connections with cerebral regions affected by neurodegenerative diseases, this study investigated the cerebellar contribution to cognitive decline in Alzheimer’s disease (AD). This study retrospectively analysed 127 individuals with subjective cognitive decline (SCD, n = 46), mild cognitive impairment due to AD (MCI, n = 24), and AD dementia (ADD, n = 57).

The endophilin-A proteins (EndoAs) are Bin/Amphiphysin/Rvs (BAR) domain proteins with key roles in both clathrin-ediated (CME) and clathrin-independent endocytosis (CIE). Humans have three differentially expressed EndoAs, EndoA1, -A2, and -A3, encoded by the SH3GL2/1/3 genes, respectively. Their functions primarily arise from their N-terminal BAR domain, which senses and induces local membrane curvature, and C-terminal SH3 domain, which mediates interactions with various proline-rich domain-containing partners.