In accordance with its mission to support high level research in Belgium, the University Foundation provides financial support towards the publication in high level international journals of scientific papers which report on research in Belgian research groups. Financial support may be granted to partially cover the costs due by the author for illustrations, for page charges and for article processing fees, and for linguuistic control.
What follows is a list of articles that were subsidized recently by the University Foundation. The titles are ordered by year of publication and by title.
A Thallium-Based Screening Procedure to Identify Molecules That Modulate the Activity of Ca2+-Activated Monovalent Cation-Selective Channels
Philippaert, K. et al. (2018) A Thallium-Based Screening Procedure to Identify Molecules That Modulate the Activity of Ca2+-Activated Monovalent Cation-Selective Channels. SLAS Discovery.
TRPM5 functions as a calcium-activated monovalent cation-selective ion channel and is expressed in a variety of cell types. Dysfunction of this type of channel has been recently implied in cardiac arrhythmias, diabetes, and other pathologies. Therefore, a growing interest has emerged to develop the pharmacology of these ion channels. We optimized a screening assay based on the thallium flux through the TRPM5 channel and a fluorescent thallium dye as a probe for channel activity.
Assessment of medication adherence and responsible use of isotretinoin and contraception through Belgian community pharmacies by using pharmacy refill data
Biset, N. et al. (2018) Assessment of medication adherence and responsible use of isotretinoin and contraception through Belgian community pharmacies by using pharmacy refill data. Patient Preference and Adherence 12 153–161.
Purpose: The aims of the study were to evaluate medication adherence and the influencing factors for isotretinoin and contraception (oral, patches, and rings) and to evaluate the concomitant use of contraception and isotretinoin.
Gilissen, J. et al. How to achieve the desired outcomes of advance care planning in nursing homes: a theory of change BMC Geriatrics (2018, 18:47 DOI 10.1186/s12877-018-0723-5.
Tosenberger, A. et al. (2017) A multiscale model of early cell lineage specification including cell division, npj Systems Biology and Applications (2017) 3:16 ; doi:10.1038/s41540-017-0017-0.
Embryonic development is a self-organised process during which cells divide, interact, change fate according to a complex gene regulatory network and organise themselves in a three-dimensional space. Here, we model this complex dynamic phenomenon in the context of the acquisition of epiblast and primitive endoderm identities within the inner cell mass of the preimplantation embryo in the mouse. The multiscale model describes cell division and interactions between cells, as well as biochemical reactions inside each individual cell and in the extracellular matrix.
Acinar cells in the neonatal pancreas grow by self-duplication and not by neogenesis from duct cells
Houbracken, I. and Bouwens, L. (2017) Acinar cells in the neonatal pancreas grow by self-duplication and not by neogenesis from duct cells. Scientific Reports 7, Article number: 12643. doi:10.1038/s41598-017-12721-9.
Pancreatic acinar cells secrete digestive enzymes necessary for nutrient digestion in the intestine. They are considered the initiating cell type of pancreatic cancer and are endowed with differentiation plasticity that has been harnessed to regenerate endocrine beta cells. However, there is still uncertainty about the mechanisms of acinar cell formation during the dynamic period of early postnatal development.
EEG dominant frequency peak differentiates between Alzheimer’s disease and frontotemporal lobar degeneration
Goossens, J. et al (2017) EEG dominant frequency peak differentiates between Alzheimer’s disease and frontotemporal lobar degeneration. Journal of Alzheimer’s Disease vol. 55 pp. 53-58.
We investigated the power of EEG as biomarker in differential diagnosis of Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD). EEG was recorded from 106 patients with AD or FTLD, of which 37 had a definite diagnosis, and 40 controls. Dominant frequency peaks were extracted for all 19 channels, for each subject. The average frequency of the largest dominant frequency peaks (maxpeak) was significantly lower in AD than FTLD patients and controls. Based on ROC analysis, classification could be made with diagnostic accuracy of 78.9%.
Exploring the validity of scores from the Rosenberg Self-Esteem Scale (RSES) in Burundi: A multi-strategy approach
Fromont, A. et al. (2017) Exploring the validity of scores from the Rosenberg Self-Esteem Scale (RSES) in Burundi: A multi-strategy approach. Journal of Psychology in Africa, Vol. 27, no.4, pp. 316-324.
The present study aimed to validate the Rosenberg Self-Esteem Scale (RSES) in Burundi, through a multi-strategy approach used in cross-cultural studies. Respondents were 906 health workers (men =56%; caregivers 60%). They responded to a bilingual version of RSES. We utilized Confirmatory Factorial Analysis (CFA) with structural equation modelling and a back translation test to explore the structure of the RSES and the reliability of scores from the scale.
From the 8-Hour Day to the 40-Hour Week: Legitimization Discourses of Labour Legislation between the Wars in France and Belgium
Rudischhauser, S. (2017) From the 8-Hour Day to the 40-Hour Week: Legitimization Discourses of Labour Legislation between the Wars in France and Belgium. Politics and Governance, Volume 5, Issue 1, Pages 6–14.
In the interwar period both France and Belgium passed legislation reducing the number of working hours and established a hybrid regulatory regime lending a certain degree of official authority to collective agreements. The paper analyses discourses by scholars who, as experts, were close to the political elites, and who tried to legitimize this kind of co-regulation by pointing out the inefficiency of state intervention and the epistemic authority of non-state actors.
Interleukin-15 stimulates natural killer cell-mediated killing of both human pancreatic cancer and stellate cells
Van Audenaerde, JRM et al. (2017) Interleukin-15 stimulates natural killer cell-mediated killing of both human pancreatic cancer and stellate cells. Oncotarget.
Pancreatic ductal adenocarcinoma (PDAC) is the 4th leading cause of cancerrelated death in Western countries with a 5-year survival rate below 5%. One of the hallmarks of this cancer is the strong desmoplastic reaction within the tumor microenvironment (TME), orchestrated by activated pancreatic stellate cells (PSC). This results in a functional and mechanical shield which causes resistance to conventional therapies.
Demey, L & Smessaert, H. Logical and Geometrical Distance in Polyhedral Aristotelian Diagrams in Knowledge Representation. Symmetry 2017, 9(10), 204.
Aristotelian diagrams visualize the logical relations among a finite set of objects. These diagrams originated in philosophy, but recently, they have also been used extensively in artificial intelligence, in order to study (connections between) various knowledge representation formalisms. In this paper, we develop the idea that Aristotelian diagrams can be fruitfully studied as geometrical entities. In particular, we focus on four polyhedral Aristotelian diagrams for the Boolean algebra B4, viz.
Gonze, D. et al. (2017) Multi-stability and the origin of microbial community types. The ISME Journal (doi:10.1038/ismej.2017.60)
The study of host-associated microbial community composition has suggested the presence of alternative community types. We discuss three mechanisms that could explain these observations. The most commonly invoked mechanism links community types to a response to environmental change; alternatively, community types were shown to emerge from interactions between members of local communities sampled from a metacommunity. Here, we emphasize multi-stability as a third mechanism, giving rise to different community types in the same environmental conditions.
No added diagnostic value of nonphosphorylated tau fraction (p-taurel) in CSF as a biomarker for differential dementia diagnosis
Goossens, J. et al. (2017) No added diagnostic value of nonphosphorylated tau fraction (p-taurel) in CSF as a biomarker for differential dementia diagnosis. Alzheimer's Research & Therapy 9:49
Background: The Alzheimer’s disease (AD) cerebrospinal fluid (CSF) biomarkers Aβ1–42, t-tau, and p-tau181 overlap with other diseases. New tau modifications or epitopes, such as the non-phosphorylated tau fraction (p-taurel), may improve differential dementia diagnosis. The goal of this study is to investigate if p-taurel can improve the diagnostic performance of the AD CSF biomarker panel for differential dementia diagnosis.
Hilbrands, R. et al. (2017) Pancreas and gallbladder agenesis in a newborn with semilobar holoprosencephaly, a case report. BMC Medical Genetics, DOI 10.1186/s12881-017-0419-2.
Background: Pancreatic agenesis is an extremely rare cause of neonatal diabetes mellitus and has enabled the discovery of several key transcription factors essential for normal pancreas and beta cell development.
Preclinical data on the combination of cisplatin and anti-CD70 therapy in non-small cell lung cancer as an excellent match in the era of combination therapy
Jacobs, J. at al. (2017) Preclinical data on the combination of cisplatin and anti-CD70 therapy in non-small cell lung cancer as an excellent match in the era of combination therapy. Oncotarget.
In contrast to the negligible expression of the immunomodulating protein CD70 in normal tissue, we have demonstrated constitutive overexpression of CD70 on tumor cells in a subset of primary non-small cell lung cancer (NSCLC) biopsies. This can be exploited by CD70-targeting antibody-dependent cellular cytotoxicity (ADCC)-inducing antibodies. Early clinical trials of these antibodies have already shown promising results in CD70-positive malignancies. In this study, we explored the potential of cisplatin to induce CD70 expression in NSCLC.
Desender, K. et al. (2017) Subjective experience of difficulty depends on multiple cues. Sci. Rep. 7, 44222; doi: 10.1038/srep44222.
Human cognition is characterized by subjective experiences that go along with our actions, but the nature and stability of these experiences remain largely unclear. In the current report, the subjective experience of difficulty is studied and it is proposed that this experience is constructed by integrating information from multiple cues.