Scientific papers

In accordance with its mission to support high level research in Belgium, the University Foundation provides financial support towards the publication in high level international journals of scientific papers which report on research in Belgian research groups. Financial support may be granted to partially cover the costs due by the author for illustrations, for page charges and for article processing fees, and for linguuistic control. 

Because the possible support is restricted to Belgian research groups, the regulations and application procedures are only available in French  and in Dutch.

Articles subsidized by the University Foundation

What follows is a list of articles that were subsidized recently by the University Foundation. The titles are ordered by year of publication and by title.

Malgorzata KLASS, Vitalie FAORO, Alain CARPENTIER
Klass M., Faoro V., Carpentier A. (2019) Assessment of energy expenditure during high intensity cycling and running using a heart rate and activity monitor in young active adults. PLoS ONE 14(11): e0224948.
Objective
Although high intensity physical activities may represent a great proportion of the total energy expenditure in active people, only sparse studies have investigated the accuracy of wearable monitors to assess activity related energy expenditure (AEE) during high intensity exercises. Therefore, the purpose of the present study was to investigate the accuracy of the Actiheart, a light portable monitor estimating AEE based on heart rate (HR) and activity
Lynn Germeys, Yannick Griep & Sara De Gieter

Germeys, L. et al. (2019) Citizenship Pressure as a Predictor of Daily Enactment of Autonomous and Controlled Organizational Citizenship Behavior: Differential Spillover Effects on the Home Domain. Frontiers in Psychology https://doi.org/10.3389/fpsyg.2019.00395.

This study questions the exclusive discretionary nature of organizational citizenship behavior (OCB) by differentiating between autonomous OCB (performed spontaneously) and controlled OCB (performed in response to a request from others). We examined whether citizenship pressure evokes the performance of autonomous and controlled OCB, and whether both OCB types have different effects on employees’ experience of work-home conflict and work-home enrichment at the within- and between-person level of analysis.

Jinthe Van Loenhout et al.

Jinthe Van Loenhout J. et al. (2019) Cold Atmospheric Plasma-Treated PBS Eliminates Immunosuppressive Pancreatic Stellate Cells and Induces Immunogenic Cell Death of Pancreatic Cancer CellsCancers 2019, 11, 1597; doi:10.3390/cancers11101597

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers with a low response to treatment and a five-year survival rate below 5%. The ineectiveness of treatment is partly because of an immunosuppressive tumor microenvironment, which comprises tumor-supportive pancreatic stellate cells (PSCs). Therefore, new therapeutic strategies are needed to tackle both the immunosuppressive PSC and pancreatic cancer cells (PCCs). Recently, physical cold atmospheric plasma consisting of reactive oxygen and nitrogen species has emerged as a novel treatment option for cancer.
Annelore Van Nieuwenhove et al.

Van Nieuwenhove, A. et al. (2019) Cryptic diversity and limited connectivity in octopuses: Recommendations for fisheries management. Plos One, May 2019.

The market demand for octopus grows each year, but landings are decreasing, and prices are rising. The present study investigated (1) diversity of Octopodidae in the Western Indian Ocean (WIO) and (2) connectivity and genetic structure of Octopus cyanea and O. vulgaris populations in order to obtain baseline data for management plans. A fragment of the cytochrome C oxidase subunit 1 (COI) gene was sequenced in 275 octopus individuals from Madagascar, Kenya and Tanzania.

Jeroen Van Schependom, Kaat Guldolf, Marie Béatrice D’hooghe, Guy Nagels and Miguel D’haeseleer

Van Schependom, J. et al. Detecting neurodegenerative pathology in multiple sclerosis before irreversible brain tissue loss sets inTransl Neurodegener 8, 37 (2019) doi:10.1186/s40035-019-0178-4 and 9, 3 (2020) doi:10.1186/s40035-019-0182-8.

Abstract
Background: Multiple sclerosis (MS) is a complex chronic inflammatory and degenerative disorder of the central nervous system. Accelerated brain volume loss, or also termed atrophy, is currently emerging as a popular imaging marker of neurodegeneration in affected patients, but, unfortunately, can only be reliably interpreted at the time when irreversible tissue damage likely has already occurred. Timing of treatment decisions based on brain atrophy
may therefore be viewed as suboptimal.
Lucille Desbouys et al.

Desbouys, L.; De Ridder, K.; Rouche, M.; Castetbon, K. (2019) Food Consumption in Adolescents and Young Adults: Age-Specific Socio-Economic and Cultural Disparities (Belgian Food Consumption Survey 2014)Nutrients11, 1520.

A key issue in nutritional public health policies is to take into account social disparities behind health inequalities. The transition from adolescence toward adulthood is a critical period regarding changes in health behaviors. This study aimed to determine how consumption of four emblematic food groups (two to favor and two to limit) differed according to socio-economic and cultural characteristics of adolescents and young adults living in Belgium.

Jonas Schoelynck e.a.

Schoelynck, J.  e.a. (2019) Hippos (Hippopotamus amphibius): The animal silicon pump, Science Advances  01 May 2019: Vol. 5, no. 5, eaav0395 DOI: 10.1126/sciadv.aav0395.

While the importance of grasslands in terrestrial silicon (Si) cycling and fluxes to rivers is established, the influence of large grazers has not been considered. Here, we show that hippopotamuses are key actors in the savannah biogeochemical Si cycle. Through a detailed analysis of Si concentrations and stable isotope compositions in multiple ecosystem compartments of a savannah-river continuum, we constrain the processes influencing the Si flux. Hippos transport 0.4 metric tons of Si day−1 by foraging grass on land and directly egesting in the water.

A.L. Jacquemart et al.

Jacquemart A.L.et al. (2019) Male flowers of Aconitum compensate for toxic pollen with increased floral signals and rewards for pollinators.Scientific reports 9:16498 | https://doi.org/10.1038/s41598-019-53355-3.

Many plants require animal pollinators for successful reproduction; these plants provide pollinator resources in pollen and nectar (rewards) and attract pollinators by specific cues (signals). In a seeming contradiction, some plants produce toxins such as alkaloids in their pollen and nectar, protecting their resources from ineffective pollinators.
Carole Charavet et al.

Charavet, C. et al (2019) Multilevel biological responses following piezocision to accelerate orthodontic tooth movement: A study in rats. Journal of the World Federation of Orthodontists. https://doi.org/10.1016/j.ejwf.2019.07.002.

Aim The objective of the present study was to explore the alveolar bone tissue response and its dynamic at the tissue, cellular, and molecular levels following a piezocision procedure in a rat model.

Sophie Opsomer, Peter Pype, Emelien Lauwerier, and Jan De Lepeleire

Opsomer, S. et al. (2019) Resilience in middle-aged partners of patients diagnosed with incurable cancer: A thematic analysis. PLoS One, Aug. 14, 2019.

Background Providing care for patients with advanced cancer is often the responsibility of the partner. Being confronted with an incurable cancer diagnosis can be highly disruptive for the patient’s partner and can be considered a potentially traumatic event. However, most caregivers seem to adapt well during the process of providing care. This finding is in line with the concept of resilience in literature: a dynamic process of adapting well, resulting from the interplay between intrinsic and extrinsic resources and risks.

Maria Papadopoulou, Paola Tieppo, Naomi McGovern, Françoise Gosselin, Jerry K. Y. Chan, Glenn Goetgeluk, Nicolas Dauby, Alexandra Cogan, Catherine Donner, Florent Ginhoux, Bart Vandekerckhove and David Vermijlen

Papadopoulou, M. et al. (2019) TCR Sequencing Reveals the Distinct Development of Fetal and Adult Human Vγ9Vδ2 T Cells. The Journal of Immunology, 203: 1468–1479. doi: 10.4049/jimmunol.1900592

Phosphoantigen-reactive Vγ9Vδ2 T cells represent the main innate human gd T cell subset and dominate the fetal and adult peripheral blood γδ T cell repertoire.

R. Neville et al.

Nivelle R. et al. (2019) Temperature preference of Nile tilapia (Oreochromis niloticus) juveniles induces spontaneous sex reversal. PLoS ONE 14(2): e0212504. https://doi.org/10.1371/journal.pone.0212504

Nile tilapia (Oreochromis niloticus) is an African freshwater fish that displays a genetic sex determination system (XX|XY) where high temperatures (above 32°C to 36.5°C) induce masculinization. In Nile tilapia, the thermosensitive period was reported from 10 to 30 days post fertilization. In their natural environment, juveniles may encounter high temperatures that are above the optimal temperature for growth (27–30°C). The relevance of the thermal sex reversal mechanism in a natural context remains unclear.

M. Quinet et al.

Quinet M. et al. (2019) Tomato Fruit Development and MetabolismFrontiers in Plant Science 10:1554, doi: 10.3389/fpls.2019.01554.

Tomato (Solanum lycopersicum L.) belongs to the Solanaceae family and is the second most important fruit or vegetable crop next to potato (Solanum tuberosum L.). It is cultivated for fresh fruit and processed products. Tomatoes contain many healthpromoting compounds including vitamins, carotenoids, and phenolic compounds. In addition to its economic and nutritional importance, tomatoes have become the model for the study of fleshy fruit development. Tomato is a climacteric fruit and dramatic metabolic changes occur during its fruit development.
Vabutsele, G. et al.

Vanbutsele, G. et al. (2019) Use and timing of referral to specialized palliative care services for people with cancer: A mortality follow-back study among treating physicians in Belgium. Plos One.

Background
Referral to specialized palliative care services (SPCS) occurs often late in the illness trajectory but may differ across cancer types. We examined differences between cancer types in the use and timing of referral to specialized palliative care services (SPCS) and in the reasons for non-referral.

Charisse Somers, Piotr Lewczuk, Anne Sieben, Christine Van Broeckhoven, Peter Paul De Deyn, Johannes Kornhuber, Jean-Jacques Martin, Maria Bjerke and Sebastiaan Engelborghs

Somers, C., Van Broeckhoven, C., Engelborghs, S et al. (2019) Validation of the Erlangen Score Algorithm for Differential Dementia Diagnosis in Autopsy-Confirmed Subjects. Journal of Alzheimer’s Disease 68, 1151–1159. DOI 10.3233/JAD-180563

Abstract
Background: Despite decades of research on the optimization of the diagnosis of Alzheimer’s disease (AD), its biomarkerbased diagnosis is being hampered by the lack of comparability of raw biomarker data. In order to overcome this limitation, the Erlangen Score (ES), among other approaches, was set up as a diagnostic-relevant interpretation algorithm.
Objective: To validate the ES algorithm in a cohort of neuropathologically confirmed cases with AD (n = 106) and non-AD dementia (n = 57).

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